Buffering Mitigates Chondrocyte Oxidative Stress, Metabolic Dysfunction, and Death Induced by Normal Saline: Formulation of a Novel Arthroscopic Irrigant

Buffering Mitigates Chondrocyte Oxidative Stress, Metabolic Dysfunction, and Death Induced by Normal Saline: Formulation of a Novel Arthroscopic Irrigant

For decades, surgeons have utilized 0.9% normal saline (NS) for joint irrigation to improve visualization during arthroscopic procedures. This continues despite mounting evidence that NS exposure impairs chondrocyte metabolism and compromises articular cartilage function. We hypothesized that chondr...

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Bibliographic Details
Main Authors: Arman Hlas, Venkateswaran Ganesh, Jaison Marks, Rui He, Aliasger K. Salem, Joseph A. Buckwalter, Kyle R. Duchman, Kyungsup Shin, James A. Martin, Dongrim Seol
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:International Journal of Molecular Sciences
Subjects:
arthroscopic irrigation
normal saline
acidity
oxidative stress
metabolic dysfunction
cell death
Online Access:https://www.mdpi.com/1422-0067/25/2/1286

Internet

https://www.mdpi.com/1422-0067/25/2/1286

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