Ethanol extract of Andrographis paniculata alleviates aluminum-induced neurotoxicity and cognitive impairment through regulating the p62-keap1-Nrf2 pathway

Ethanol extract of Andrographis paniculata alleviates aluminum-induced neurotoxicity and cognitive impairment through regulating the p62-keap1-Nrf2 pathway

Abstract Background Alzheimer’s disease (AD) is the most prevalent neurodegenerative and remains incurable. Aluminum is a potent neurotoxin associated with AD. The main pathological features of AD are extracellular amyloid-β protein deposition and intracellular hyperphosphorylated Tau protein. A bod...

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Bibliographic Details
Main Authors: Jianping Ma, Miao Zheng, Xinyue Zhang, Jiaqi Lu, Lili Gu
Format: Article
Language:English
Published: BMC 2023-12-01
Series:BMC Complementary Medicine and Therapies
Subjects:
Aluminum
Neuroprotective
Cognitive dysfunction
Andrographis paniculata
Andrographolide
Autophagy
Online Access:https://doi.org/10.1186/s12906-023-04290-4

Internet

https://doi.org/10.1186/s12906-023-04290-4

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