mRNA PROTACs: engineering PROTACs for high‐efficiency targeted protein degradation

mRNA PROTACs: engineering PROTACs for high‐efficiency targeted protein degradation

Abstract Proteolysis‐targeting chimeras (PROTACs) are essential bifunctional molecules that target proteins of interest (POIs) for degradation by cellular ubiquitination machinery. Despite significant progress made in understanding PROTACs' functions, their therapeutic potential remains largely...

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Bibliographic Details
Main Authors: Xiaoqi Xue, Chen Zhang, Xiaolin Li, Junqiao Wang, Haowei Zhang, Ying Feng, Naihan Xu, Hongyan Li, Chunyan Tan, Yuyang Jiang, Ying Tan
Format: Article
Language:English
Published: Wiley 2024-02-01
Series:MedComm
Subjects:
in vitro transcribed mRNA (IVT‐mRNA)
mRNA
peptide proteolysis‐argeting chimeras
proteolysis‐argeting chimeras (PROTAC)
Targeted protein degradation (TPD)
Online Access:https://doi.org/10.1002/mco2.478

Internet

https://doi.org/10.1002/mco2.478

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