CTCF as a boundary factor for cohesin-mediated loop extrusion: evidence for a multi-step mechanism
Mammalian genome structure is closely linked to function. At the scale of kilobases to megabases, CTCF and cohesin organize the genome into chromatin loops. Mechanistically, cohesin is proposed to extrude chromatin loops bidirectionally until it encounters occupied CTCF DNA-binding sites. Curiously,...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-01-01
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| Series: | Nucleus |
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| Online Access: | http://dx.doi.org/10.1080/19491034.2020.1782024 |