O-GlcNAcylation enhances sensitivity to RSL3-induced ferroptosis via the YAP/TFRC pathway in liver cancer

O-GlcNAcylation enhances sensitivity to RSL3-induced ferroptosis via the YAP/TFRC pathway in liver cancer

Abstract Ferroptosis is a form of regulated cell death characterized by iron-dependent accumulation of lipid hydroperoxides to lethal levels. YAP has been reported to play a pivotal role in controlling ferroptotic death, and the expression of YAP is enhanced and stabilized by O-GlcNAcylation. Howeve...

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Bibliographic Details
Main Authors: Guoqing Zhu, Abduh Murshed, Haojie Li, Ji Ma, Ni Zhen, Miao Ding, Jiabei Zhu, Siwei Mao, Xiaochen Tang, Li Liu, Fenyong Sun, Lei Jin, Qiuhui Pan
Format: Article
Language:English
Published: Nature Publishing Group 2021-04-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-021-00468-2

Internet

https://doi.org/10.1038/s41420-021-00468-2

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