Unraveling the unphosphorylated STAT3–unphosphorylated NF-κB pathway in loss of function STAT3 Hyper IgE syndrome

Unraveling the unphosphorylated STAT3–unphosphorylated NF-κB pathway in loss of function STAT3 Hyper IgE syndrome

BackgroundPatients with loss of function signal transducer and activator of transcription 3-related Hyper IgE Syndrome (LOF STAT3 HIES) present with recurrent staphylococcal skin and pulmonary infections along with the elevated serum IgE levels, eczematous rashes, and skeletal and facial abnormaliti...

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Bibliographic Details
Main Authors: Adil Karim, Rashi Garg, Biman Saikia, Abha Tiwari, Smrity Sahu, Mehak Malhotra, Ranjana W. Minz, Amit Rawat, Surjit Singh, Deepti Suri
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-08-01
Series:Frontiers in Immunology
Subjects:
inborn error of immunity (IEI)
primary immunodeficencies (PID)
Hyper IgE syndrome (HIES)
signal transducer and activator of transcription 3 (STAT3)
Regulated upon Activation
normal T-cell expressed and secreted chemokines (RANTES)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1332817/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1332817/full

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