Canonical Bcl-2 Motifs of the Na+/K+ Pump Revealed by the BH3 Mimetic Chelerythrine: Early Signal Transducers of Apoptosis?

Canonical Bcl-2 Motifs of the Na+/K+ Pump Revealed by the BH3 Mimetic Chelerythrine: Early Signal Transducers of Apoptosis?

Background/Aims: Chelerythrine [CET], a protein kinase C [PKC] inhibitor, is a prop-apoptotic BH3-mimetic binding to BH1-like motifs of Bcl-2 proteins. CET action was examined on PKC phosphorylation-dependent membrane transporters (Na+/K+ pump/ATPase [NKP, NKA], Na+-K+-2Cl+ [NKCC] and K+-Cl- [KCC] c...

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Bibliographic Details
Main Authors: Peter K. Lauf, Judith Heiny, Jarek Meller, Michael A. Lepera, Leonid Koikov, Gerald M. Alter, Thomas L. Brown, Norma C. Adragna
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2013-02-01
Series:Cellular Physiology and Biochemistry
Subjects:
Chelerythrine
Na+/K+ Pump-ATPase
NKCC1
KCC
K+ Channels
Bcl-2 Proteins
Apoptosis
Human Lens Epithelia
Online Access:http://www.karger.com/Article/FullText/343366

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http://www.karger.com/Article/FullText/343366

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