CSGID Solves Structures and Identifies Phenotypes for Five Enzymes in Toxoplasma gondii

CSGID Solves Structures and Identifies Phenotypes for Five Enzymes in Toxoplasma gondii

Toxoplasma gondii, an Apicomplexan parasite, causes significant morbidity and mortality, including severe disease in immunocompromised hosts and devastating congenital disease, with no effective treatment for the bradyzoite stage. To address this, we used the Tropical Disease Research database, crys...

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Main Authors: Joseph D. Lykins, Ekaterina V. Filippova, Andrei S. Halavaty, George Minasov, Ying Zhou, Ievgeniia Dubrovska, Kristin J. Flores, Ludmilla A. Shuvalova, Jiapeng Ruan, Kamal El Bissati, Sarah Dovgin, Craig W. Roberts, Stuart Woods, Jon D. Moulton, Hong Moulton, Martin J. McPhillie, Stephen P. Muench, Colin W. G. Fishwick, Elisabetta Sabini, Dhanasekaran Shanmugam, David S. Roos, Rima McLeod, Wayne F. Anderson, Huân M. Ngô
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Toxoplasma gondii
PPMO
phosphoglycerate mutase
nucleoside diphoshate kinase
ribulose-3-phosphate epimerase
ribose-5-phosphate isomerase
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2018.00352/full

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https://www.frontiersin.org/article/10.3389/fcimb.2018.00352/full

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