In vivo imaging of mitochondrial DNA mutations using an integrated nano Cas12a sensor

In vivo imaging of mitochondrial DNA mutations using an integrated nano Cas12a sensor

Abstract Mutations in mitochondrial DNA (mtDNA) play critical roles in many human diseases. In vivo visualization of cells bearing mtDNA mutations is important for resolving the complexity of these diseases, which remains challenging. Here we develop an integrated nano Cas12a sensor (InCasor) and sh...

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Bibliographic Details
Main Authors: Yanan Li, Yonghua Wu, Ru Xu, Jialing Guo, Fenglei Quan, Yongyuan Zhang, Di Huang, Yiran Pei, Hua Gao, Wei Liu, Junjie Liu, Zhenzhong Zhang, Ruijie Deng, Jinjin Shi, Kaixiang Zhang
Format: Article
Language:English
Published: Nature Portfolio 2023-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-43552-0

Internet

https://doi.org/10.1038/s41467-023-43552-0

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