Cholesterol-Depletion-Induced Membrane Repair Carries a Raft Conformer of P-Glycoprotein to the Cell Surface, Indicating Enhanced Cholesterol Trafficking in MDR Cells, Which Makes Them Resistant to Cholesterol Modifications

Cholesterol-Depletion-Induced Membrane Repair Carries a Raft Conformer of P-Glycoprotein to the Cell Surface, Indicating Enhanced Cholesterol Trafficking in MDR Cells, Which Makes Them Resistant to Cholesterol Modifications

The human P-glycoprotein (P-gp), a transporter responsible for multidrug resistance, is present in the plasma membrane’s raft and non-raft domains. One specific conformation of P-gp that binds to the monoclonal antibody UIC2 is primarily associated with raft domains and displays heightened internali...

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Bibliographic Details
Main Authors: Zsuzsanna Gutay-Tóth, Gabriella Gellen, Minh Doan, James F. Eliason, János Vincze, Lajos Szente, Ferenc Fenyvesi, Katalin Goda, Miklós Vecsernyés, Gábor Szabó, Zsolt Bacso
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:International Journal of Molecular Sciences
Subjects:
ABCB1 transporter
cyclodextrin
membrane repair
raft
trafficking
UIC2
Online Access:https://www.mdpi.com/1422-0067/24/15/12335

Internet

https://www.mdpi.com/1422-0067/24/15/12335

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