Cholesterol-Depletion-Induced Membrane Repair Carries a Raft Conformer of P-Glycoprotein to the Cell Surface, Indicating Enhanced Cholesterol Trafficking in MDR Cells, Which Makes Them Resistant to Cholesterol Modifications
The human P-glycoprotein (P-gp), a transporter responsible for multidrug resistance, is present in the plasma membrane’s raft and non-raft domains. One specific conformation of P-gp that binds to the monoclonal antibody UIC2 is primarily associated with raft domains and displays heightened internali...
Main Authors: | Zsuzsanna Gutay-Tóth, Gabriella Gellen, Minh Doan, James F. Eliason, János Vincze, Lajos Szente, Ferenc Fenyvesi, Katalin Goda, Miklós Vecsernyés, Gábor Szabó, Zsolt Bacso |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2023-08-01
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Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/24/15/12335 |
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