Extracellular vesicles from mesenchymal stem cells reduce neuroinflammation in hippocampus and restore cognitive function in hyperammonemic rats

Extracellular vesicles from mesenchymal stem cells reduce neuroinflammation in hippocampus and restore cognitive function in hyperammonemic rats

Abstract Chronic hyperammonemia, a main contributor to hepatic encephalopathy (HE), leads to neuroinflammation which alters neurotransmission leading to cognitive impairment. There are no specific treatments for the neurological alterations in HE. Extracellular vesicles (EVs) from mesenchymal stem c...

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Bibliographic Details
Main Authors: Paula Izquierdo-Altarejos, Andrea Cabrera-Pastor, Mar Martínez-García, Carlos Sánchez-Huertas, Alberto Hernández, Victoria Moreno-Manzano, Vicente Felipo
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Journal of Neuroinflammation
Subjects:
Hyperammonemia
Neuroinflammation
Cognitive impairment
Extracellular vesicles
Mesenchymal stem cells
Online Access:https://doi.org/10.1186/s12974-022-02688-4

Internet

https://doi.org/10.1186/s12974-022-02688-4

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