Modulation of Hippocampal Astroglial Activity by Synaptamide in Rats with Neuropathic Pain

The present study demonstrates that synaptamide (N-docosahexaenoylethanolamine), an endogenous metabolite of docosahexaenoic acid, when administered subcutaneously (4 mg/kg/day, 14 days), exhibits analgesic activity and promotes cognitive recovery in the rat sciatic nerve chronic constriction injury...

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Bibliographic Details
Main Authors: Igor Manzhulo, Olga Manzhulo, Anna Tyrtyshnaia, Arina Ponomarenko, Sophia Konovalova, Ekaterina Ermolenko, Elena Milkina, Anna Starinets
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Brain Sciences
Subjects:
Online Access:https://www.mdpi.com/2076-3425/11/12/1561