Modulation of Hippocampal Astroglial Activity by Synaptamide in Rats with Neuropathic Pain

Modulation of Hippocampal Astroglial Activity by Synaptamide in Rats with Neuropathic Pain

The present study demonstrates that synaptamide (N-docosahexaenoylethanolamine), an endogenous metabolite of docosahexaenoic acid, when administered subcutaneously (4 mg/kg/day, 14 days), exhibits analgesic activity and promotes cognitive recovery in the rat sciatic nerve chronic constriction injury...

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Bibliographic Details
Main Authors:	Igor Manzhulo, Olga Manzhulo, Anna Tyrtyshnaia, Arina Ponomarenko, Sophia Konovalova, Ekaterina Ermolenko, Elena Milkina, Anna Starinets
Format:	Article
Language:	English
Published:	MDPI AG 2021-11-01
Series:	Brain Sciences
Subjects:	N-docosahexaenoylethanolamine DHEA synaptamide chronic constriction injury neuropathic pain hippocampus
Online Access:	https://www.mdpi.com/2076-3425/11/12/1561

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