Neurofilament light chain concentration mediates the association between regional medial temporal lobe structure and memory in adults with Down syndrome

Neurofilament light chain concentration mediates the association between regional medial temporal lobe structure and memory in adults with Down syndrome

Abstract INTRODUCTION Virtually all people with Down syndrome (DS) develop neuropathology associated with Alzheimer's disease (AD). Atrophy of the hippocampus and entorhinal cortex (EC), as well as elevated plasma concentrations of neurofilament light chain (NfL) protein, are markers of neurode...

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Main Authors: Natalie DiProspero, Mithra Sathishkumar, John Janecek, Anna Smith, Liv McMillan, Melissa Petersen, Nicholas Tustison, David B. Keator, Eric Doran, Christy L. Hom, Dana Nguyen, Howard Andrews, Sharon Krinsky‐McHale, Adam M. Brickman, H. Diana Rosas, Florence Lai, Elizabeth Head, Mark Mapstone, Wayne Silverman, Ira T. Lott, Sid O'Bryant, Michael A. Yassa
Format: Article
Language:English
Published: Wiley 2024-01-01
Series:Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
Subjects:
Alzheimer's disease
anterolateral entorhinal cortex
cognitive decline
dementia
Down syndrome
episodic memory
Online Access:https://doi.org/10.1002/dad2.12542

Internet

https://doi.org/10.1002/dad2.12542

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