Exercise Training Stabilizes RyR2-Dependent Ca2+ Release in Post-infarction Heart Failure

Aim: Dysfunction of the cardiac ryanodine receptor (RyR2) is an almost ubiquitous finding in animal models of heart failure (HF) and results in abnormal Ca2+ release in cardiomyocytes that contributes to contractile impairment and arrhythmias. We tested whether exercise training (ET), as recommended...

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Bibliographic Details
Main Authors: Tore Kristian Danielsen, Mani Sadredini, Ravinea Manotheepan, Jan Magnus Aronsen, Michael Frisk, Marie Haugsten Hansen, Kjetil Wessel Andressen, Karina Hougen, Finn Olav Levy, William E. Louch, Ole Mathias Sejersted, Ivar Sjaastad, Mathis Korseberg Stokke
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2020.623922/full