Ultrastructural and proapoptotic-like effects of kaempferol in Giardia duodenalis trophozoites and bioinformatics prediction of its potential protein target

Ultrastructural and proapoptotic-like effects of kaempferol in Giardia duodenalis trophozoites and bioinformatics prediction of its potential protein target

BACKGROUND Kaempferol (KPF) is a flavonoid with antiparasitic activity including experimental giardiasis which mechanism of action is unknown. OBJECTIVE To analyse the cytotoxic effects of KPF on Giardia duodenalis trophozoites and to identify a likely parasite target of this compound. METHODS W...

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Bibliographic Details
Main Authors: Raúl Argüello-García, Fernando Calzada, Normand García-Hernández, Bibiana Chávez-Munguía, José Antonio Velázquez-Domínguez
Format: Article
Language:English
Published: Fundação Oswaldo Cruz (FIOCRUZ) 2020-10-01
Series:Memorias do Instituto Oswaldo Cruz
Subjects:
kaempferol
Giardia duodenalis
aldose reductase
reactive oxygen species
apoptosis-like
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762020000100343&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762020000100343&tlng=en

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