FBXO9 Mediates the Cancer-Promoting Effects of ZNF143 by Degrading FBXW7 and Facilitates Drug Resistance in Hepatocellular Carcinoma

FBXO9 Mediates the Cancer-Promoting Effects of ZNF143 by Degrading FBXW7 and Facilitates Drug Resistance in Hepatocellular Carcinoma

F-box proteins are critical for malignancy because they control the turnover of key proteins that govern multiple cellular processes. F-box protein 9 (FBXO9) belongs to the F-box protein family and exhibits oncogenic properties in hematological malignancies. However, the function and molecular mecha...

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Bibliographic Details
Main Authors: Zhenyu Wang, Xiaoxia Chen, Lianer Zhou, Xinge Zhao, Chao Ge, Fangyu Zhao, Haiyang Xie, Taoyang Chen, Hua Tian, Hong Li, Jinjun Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Oncology
Subjects:
hepatocellular carcinoma
FBXO9
ZNF143
FBXW7
ubiquitin-proteasome mediated degradation
Lenvatinib
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.930220/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.930220/full

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