Targeting G-quadruplexes with Organic Dyes: Chelerythrine–DNA Binding Elucidated by Combining Molecular Modeling and Optical Spectroscopy

Targeting G-quadruplexes with Organic Dyes: Chelerythrine–DNA Binding Elucidated by Combining Molecular Modeling and Optical Spectroscopy

The DNA-binding of the natural benzophenanthridine alkaloid chelerythrine (CHE) has been assessed by combining molecular modeling and optical absorption spectroscopy. Specifically, both double-helical (B-DNA) and G-quadruplex sequences—representative of different topologies and possessing...

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Bibliographic Details
Main Authors: Alessio Terenzi, Hugo Gattuso, Angelo Spinello, Bernhard K. Keppler, Christophe Chipot, François Dehez, Giampaolo Barone, Antonio Monari
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Antioxidants
Subjects:
guanine quadruplexes
anticancer drugs
all atom molecular dynamics
circular dichroism
Online Access:https://www.mdpi.com/2076-3921/8/10/472

Internet

https://www.mdpi.com/2076-3921/8/10/472

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