Functional and evolutionary significance of human microRNA seed region mutations.

MicroRNAs have emerged in recent years as important regulators of cell function in both normal and diseased cells. MiRNAs coordinately regulate large suites of target genes by mRNA degradation and/or translational inhibition. The mRNA target specificities of miRNAs in animals are primarily encoded w...

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Bibliographic Details
Main Authors: Christopher G Hill, Neda Jabbari, Lilya V Matyunina, John F McDonald
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4264867?pdf=render