Loss, Gain and Altered Function of GlyR α2 Subunit Mutations in Neurodevelopmental Disorders

Loss, Gain and Altered Function of GlyR α2 Subunit Mutations in Neurodevelopmental Disorders

Glycine receptors (GlyRs) containing the α2 subunit govern cell fate, neuronal migration and synaptogenesis in the developing cortex and spinal cord. Rare missense variants and microdeletions in the X-linked GlyR α2 subunit gene (GLRA2) have been associated with human autism spectrum disorder (ASD),...

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Bibliographic Details
Main Authors: Xiumin Chen, Katie A. Wilson, Natascha Schaefer, Lachlan De Hayr, Mark Windsor, Emmanuel Scalais, Germaine van Rijckevorsel, Katrien Stouffs, Carmen Villmann, Megan L. O’Mara, Joseph W. Lynch, Robert J. Harvey
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Molecular Neuroscience
Subjects:
autism spectrum disorder
developmental disorders
epilepsy
glycine receptor (GlyR)
GLRA2
GlyR α2 subunit
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2022.886729/full

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https://www.frontiersin.org/articles/10.3389/fnmol.2022.886729/full

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