New 5-Hydroxycoumarin-Based Tyrosyl-DNA Phosphodiesterase I Inhibitors Sensitize Tumor Cell Line to Topotecan

New 5-Hydroxycoumarin-Based Tyrosyl-DNA Phosphodiesterase I Inhibitors Sensitize Tumor Cell Line to Topotecan

Tyrosyl-DNA-phosphodiesterase 1 (TDP1) is an important enzyme in the DNA repair system. The ability of the enzyme to repair DNA damage induced by a topoisomerase 1 poison such as the anticancer drug topotecan makes TDP1 a promising target for complex antitumor therapy. In this work, a set of new 5-h...

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Bibliographic Details
Main Authors: Tatyana M. Khomenko, Alexandra L. Zakharenko, Tatyana E. Kornienko, Arina A. Chepanova, Nadezhda S. Dyrkheeva, Anastasia O. Artemova, Dina V. Korchagina, Chigozie Achara, Anthony Curtis, Jóhannes Reynisson, Konstantin P. Volcho, Nariman F. Salakhutdinov, Olga I. Lavrik
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:International Journal of Molecular Sciences
Subjects:
coumarin
monoterpene
enzyme inhibition
DNA repair
synergy
Online Access:https://www.mdpi.com/1422-0067/24/11/9155

Internet

https://www.mdpi.com/1422-0067/24/11/9155

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