Enhanced pharmacokinetic performance of dapoxetine hydrochloride via the formulation of instantly-dissolving buccal films with acidic pH modifier and hydrophilic cyclodextrin: Factorial analysis, in vitro and in vivo assessment

Enhanced pharmacokinetic performance of dapoxetine hydrochloride via the formulation of instantly-dissolving buccal films with acidic pH modifier and hydrophilic cyclodextrin: Factorial analysis, in vitro and in vivo assessment

Instantly dissolving buccal films have gained attention owing to their easy administration and capability to surmount the hepatic first pass effect of drugs. Dapoxetine hydrochloride (DPX) has a low oral bioavailability due to significant hepatic first pass metabolism. In addition, DPX is a weakly b...

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Bibliographic Details
Main Authors: Hibah M. Aldawsari, Shaimaa M. Badr-Eldin
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Journal of Advanced Research
Subjects:
Dapoxetine hydrochloride
Microenvironmental pH
Hydroxypropyl methyl cellulose E5
Maltodextrin
In vivo mouth dissolving time
Mechanical properties
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123220300813

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http://www.sciencedirect.com/science/article/pii/S2090123220300813

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