Regulation of endothelial nitric oxide synthase gene expression by oxidized linoleic acid

Hypercholesterolemia is associated with impairments in endothelium-dependent vascular relaxations. Paradoxically, endothelial production of nitrogen oxides is increased in early stages of hypercholesterolemia. Prior work has shown that oxidized low density lipoprotein (LDL) has both stimulatory and...

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Bibliographic Details
Main Authors: Santhini Ramasamy, Sampath Parthasarathy, David G. Harrison
Format: Article
Language:English
Published: Elsevier 1998-02-01
Series:Journal of Lipid Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520338888