Metabolomic Assessment Reveals Alteration in Polyols and Branched Chain Amino Acids Associated With Present and Future Renal Impairment in a Discovery Cohort of 637 Persons With Type 1 Diabetes

Metabolomic Assessment Reveals Alteration in Polyols and Branched Chain Amino Acids Associated With Present and Future Renal Impairment in a Discovery Cohort of 637 Persons With Type 1 Diabetes

Background: Improved understanding of the pathophysiology causing diabetic kidney disease (DKD) is imperative. The aim of this study was to uncover associations between serum metabolites and renal outcomes.Methods: Non-targeted serum metabolomics analyses were performed in samples from 637 persons w...

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Bibliographic Details
Main Authors: Nete Tofte, Tommi Suvitaival, Kajetan Trost, Ismo Matias Mattila, Simone Theilade, Signe Abitz Winther, Tarunveer Singh Ahluwalia, Marie Frimodt-Møller, Cristina Legido-Quigley, Peter Rossing
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Endocrinology
Subjects:
diabetic kidney disease
type 1 diabetes
metabolomics
end-stage renal disease
amino acids
polyols
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2019.00818/full

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https://www.frontiersin.org/article/10.3389/fendo.2019.00818/full

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