P-selectin-dependent leukocyte adhesion is governed by endolysosomal two-pore channel 2

P-selectin-dependent leukocyte adhesion is governed by endolysosomal two-pore channel 2

Summary: Upon proinflammatory challenges, endothelial cell surface presentation of the leukocyte receptor P-selectin, together with the stabilizing co-factor CD63, is needed for leukocyte capture and is mediated via demand-driven exocytosis from the Weibel-Palade bodies that fuse with the plasma mem...

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Bibliographic Details
Main Authors: Jonas Goretzko, Inga Pauels, Nicole Heitzig, Katharina Thomas, Marina Kardell, Johannes Naß, Einar Kleinhans Krogsaeter, Sebastian Schloer, Barbara Spix, Anna Lívia Linard Matos, Charlotte Leser, Tristan Wegner, Frank Glorius, Franz Bracher, Volker Gerke, Jan Rossaint, Christian Grimm, Ursula Rescher
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Cell Reports
Subjects:
CP: Immunology
CP: Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723015139

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http://www.sciencedirect.com/science/article/pii/S2211124723015139

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