P-selectin-dependent leukocyte adhesion is governed by endolysosomal two-pore channel 2
Summary: Upon proinflammatory challenges, endothelial cell surface presentation of the leukocyte receptor P-selectin, together with the stabilizing co-factor CD63, is needed for leukocyte capture and is mediated via demand-driven exocytosis from the Weibel-Palade bodies that fuse with the plasma mem...
Main Authors: | Jonas Goretzko, Inga Pauels, Nicole Heitzig, Katharina Thomas, Marina Kardell, Johannes Naß, Einar Kleinhans Krogsaeter, Sebastian Schloer, Barbara Spix, Anna Lívia Linard Matos, Charlotte Leser, Tristan Wegner, Frank Glorius, Franz Bracher, Volker Gerke, Jan Rossaint, Christian Grimm, Ursula Rescher |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2023-12-01
|
Series: | Cell Reports |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124723015139 |
Similar Items
-
SLC15A4 controls endolysosomal TLR7–9 responses by recruiting the innate immune adaptor TASL
by: Haobo Zhang, et al.
Published: (2023-08-01) -
A robust pipeline for high-content, high-throughput immunophenotyping reveals age- and genetics-dependent changes in blood leukocytes
by: Thomas Liechti, et al.
Published: (2023-10-01) -
Pharmacologically induced endolysosomal cholesterol imbalance through clinically licensed drugs itraconazole and fluoxetine impairs Ebola virus infection in vitro
by: Susann Kummer, et al.
Published: (2022-12-01) -
Targeting the endolysosomal host-SARS-CoV-2 interface by clinically licensed functional inhibitors of acid sphingomyelinase (FIASMA) including the antidepressant fluoxetine
by: Sebastian Schloer, et al.
Published: (2020-01-01) -
Two-pore channel-2 and inositol trisphosphate receptors coordinate Ca2+ signals between lysosomes and the endoplasmic reticulum
by: Yu Yuan, et al.
Published: (2024-01-01)