Potent immunogenicity and broad-spectrum protection potential of microneedle array patch-based COVID-19 DNA vaccine candidates encoding dimeric RBD chimera of SARS-CoV and SARS-CoV-2 variants

Potent immunogenicity and broad-spectrum protection potential of microneedle array patch-based COVID-19 DNA vaccine candidates encoding dimeric RBD chimera of SARS-CoV and SARS-CoV-2 variants

ABSTRACTBreakthrough infections by SARS-CoV-2 variants pose a global challenge to COVID-19 pandemic control, and the development of more effective vaccines of broad-spectrum protection is needed. In this study, we constructed pVAX1-based plasmids encoding receptor-binding domain (RBD) chimera of SAR...

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Bibliographic Details
Main Authors: Feng Fan, Xin Zhang, Zhiyu Zhang, Yuan Ding, Limei Wang, Xin Xu, Yaying Pan, Fang-Yuan Gong, Lin Jiang, Lingyu Kang, Zhuo Ha, Huijun Lu, Jiawang Hou, Zhihua Kou, Gan Zhao, Bin Wang, Xiao-Ming Gao
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Emerging Microbes and Infections
Subjects:
COVID-19
SARS-CoV-2
RBD chimera
DNA vaccine
microneedle
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2023.2202269

Internet

https://www.tandfonline.com/doi/10.1080/22221751.2023.2202269

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