Age-related differences in prefrontal glutamate are associated with increased working memory decay that gives the appearance of learning deficits

The ability to use past experience to effectively guide decision-making declines in older adulthood. Such declines have been theorized to emerge from either impairments of striatal reinforcement learning systems (RL) or impairments of recurrent networks in prefrontal and parietal cortex that support...

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Bibliographic Details
Main Authors: Milena Rmus, Mingjian He, Beth Baribault, Edward G Walsh, Elena K Festa, Anne GE Collins, Matthew R Nassar
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-04-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/85243