Unbiased gene expression analysis of the delayed fracture healing observed in Zucker diabetic fatty rats

Unbiased gene expression analysis of the delayed fracture healing observed in Zucker diabetic fatty rats

Aims: Impaired fracture repair in patients with type 2 diabetes mellitus (T2DM) is not fully understood. In this study, we aimed to characterize the local changes in gene expression (GE) associated with diabetic fracture. We used an unbiased approach to compare GE in the fracture callus of Zucker d...

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Bibliographic Details
Main Authors: Jonghoo Sung, Kate R. Barratt, Stephen M. Pederson, Chantal Chenu, Ines Reichert, Gerald J. Atkins, Paul H. Anderson, Peter J. Smitham
Format: Article
Language:English
Published: The British Editorial Society of Bone & Joint Surgery 2023-10-01
Series:Bone & Joint Research
Subjects:
fracture healing
fracture nonunion
zucker rats
type 2 diabetes mellitus
fracture and of the healing
gene expression
rats
mrna
inflammation
fracture callus
rna
external fixators
femoral fractures
femoral osteotomy
Online Access:https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.1210.BJR-2023-0062.R1

Internet

https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.1210.BJR-2023-0062.R1

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