Oncostatin M and STAT3 Signaling Pathways Support Human Trophoblast Differentiation by Inhibiting Inflammatory Stress in Response to IFNγ and GM-CSF

Oncostatin M and STAT3 Signaling Pathways Support Human Trophoblast Differentiation by Inhibiting Inflammatory Stress in Response to IFNγ and GM-CSF

Interleukin-6 (IL-6) superfamily cytokines play critical roles during human pregnancy by promoting trophoblast differentiation, invasion, and endocrine function, and maintaining embryo immunotolerance and protection. In contrast, the unbalanced activity of pro-inflammatory factors such as interferon...

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Bibliographic Details
Main Authors: Marion Ravelojaona, Julie Girouard, Emmanuelle Stella Kana Tsapi, Megan Chambers, Cathy Vaillancourt, Céline Van Themsche, Catherine A. Thornton, Carlos Reyes-Moreno
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Cells
Subjects:
beta-human chorionic gonadotrophin
granulocyte–macrophage colony-stimulating factor
inflammatory stress
interferon gamma
oncostatin M
pregnancy
Online Access:https://www.mdpi.com/2073-4409/13/3/229

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https://www.mdpi.com/2073-4409/13/3/229

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