The calcium channel TRPC6 promotes chemotherapy-induced persistence by regulating integrin α6 mRNA splicing

Summary: Understanding the cell biological mechanisms that enable tumor cells to persist after therapy is necessary to improve the treatment of recurrent disease. Here, we demonstrate that transient receptor potential channel 6 (TRPC6), a channel that mediates calcium entry, contributes to the prope...

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Bibliographic Details
Main Authors: Dimpi Mukhopadhyay, Hira Lal Goel, Choua Xiong, Shivam Goel, Ayush Kumar, Rui Li, Lihua Julie Zhu, Jennifer L. Clark, Michael A. Brehm, Arthur M. Mercurio
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Cell Reports
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723013591