Synthesis, Structural and Behavioral Studies of Indole Derivatives D2AAK5, D2AAK6 and D2AAK7 as Serotonin 5-HT<sub>1A</sub> and 5-HT<sub>2A</sub> Receptor Ligands

Synthesis, Structural and Behavioral Studies of Indole Derivatives D2AAK5, D2AAK6 and D2AAK7 as Serotonin 5-HT<sub>1A</sub> and 5-HT<sub>2A</sub> Receptor Ligands

Serotonin receptors are involved in a number of physiological functions and regulate aggression, anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, and thermoregulation. Here we report synthesis and detailed structural and behavioral studies of three indole derivatives: D2AAK5, D2A...

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Bibliographic Details
Main Authors: Agnieszka A. Kaczor, Ewa Kędzierska, Tomasz M. Wróbel, Angelika Grudzińska, Angelika Pawlak, Tuomo Laitinen, Agata Bartyzel
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Molecules
Subjects:
anxiety
depression
drug design
GPCRs
indole derivatives
molecular modeling
Online Access:https://www.mdpi.com/1420-3049/28/1/383

Internet

https://www.mdpi.com/1420-3049/28/1/383

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