Modulating the Activity of the Human Organic Cation Transporter 2 Emerges as a Potential Strategy to Mitigate Unwanted Toxicities Associated with Cisplatin Chemotherapy

Modulating the Activity of the Human Organic Cation Transporter 2 Emerges as a Potential Strategy to Mitigate Unwanted Toxicities Associated with Cisplatin Chemotherapy

Cisplatin (CDDP) stands out as an effective chemotherapeutic agent; however, its application is linked to the development of significant adverse effects, notably nephro- and ototoxicity. The human organic cation transporter 2 (hOCT2), found in abundance in the basolateral membrane domain of renal pr...

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Bibliographic Details
Main Authors: Anna Hucke, Marta Kantauskaite, Tim N. Köpp, Christoph A. Wehe, Uwe Karst, Pavel I. Nedvetsky, Giuliano Ciarimboli
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:International Journal of Molecular Sciences
Subjects:
cisplatin
toxicity
transport
organic cation transporter
regulation
competition
Online Access:https://www.mdpi.com/1422-0067/25/5/2922

Internet

https://www.mdpi.com/1422-0067/25/5/2922

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