β-Amyloid in blood neuronal-derived extracellular vesicles is elevated in cognitively normal adults at risk of Alzheimer’s disease and predicts cerebral amyloidosis

β-Amyloid in blood neuronal-derived extracellular vesicles is elevated in cognitively normal adults at risk of Alzheimer’s disease and predicts cerebral amyloidosis

Abstract Background Blood biomarkers that can be used for preclinical Alzheimer’s disease (AD) diagnosis would enable trial enrollment at a time when the disease is potentially reversible. Here, we investigated plasma neuronal-derived extracellular vesicle (nEV) cargo in patients along the Alzheimer...

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Bibliographic Details
Main Authors: Tao-Ran Li, Yun-Xia Yao, Xue-Yan Jiang, Qiu-Yue Dong, Xian-Feng Yu, Ting Wang, Yan-Ning Cai, Ying Han
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
Preclinical AD
Extracellular vesicle
nEVs
Blood biomarker
Aβ
Online Access:https://doi.org/10.1186/s13195-022-01010-x

Internet

https://doi.org/10.1186/s13195-022-01010-x

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