Development and Validation of a Docking-Based Virtual Screening Platform for the Identification of New Lactate Dehydrogenase Inhibitors

Development and Validation of a Docking-Based Virtual Screening Platform for the Identification of New Lactate Dehydrogenase Inhibitors

The human muscle isoform of lactate dehydrogenase (hLDH5) is one of the key enzymes of the glycolytic process. It is overexpressed in metastatic cancer cells and is linked to the vitality of tumors in hypoxic conditions. With the aim of identifying new hLDH5 inhibitors, a fully automated docking-bas...

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Bibliographic Details
Main Authors: Carlotta Granchi, Alice Capecchi, Gianluca Del Frate, Adriano Martinelli, Marco Macchia, Filippo Minutolo, Tiziano Tuccinardi
Format: Article
Language:English
Published: MDPI AG 2015-05-01
Series:Molecules
Subjects:
LDH inhibitors
virtual screening
docking
Online Access:http://www.mdpi.com/1420-3049/20/5/8772

Internet

http://www.mdpi.com/1420-3049/20/5/8772

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