Systematic Functional Analysis of <i>PINK1</i> and <i>PRKN</i> Coding Variants

Systematic Functional Analysis of <i>PINK1</i> and <i>PRKN</i> Coding Variants

Loss of either PINK1 or PRKN causes an early onset Parkinson’s disease (PD) phenotype. Functionally, PINK1 and PRKN work together to mediate stress-activated mitochondrial quality control. Upon mitochondrial damage, PINK1, a ubiquitin kinase and PRKN, a ubiquitin ligase, decorate damaged organelles...

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Bibliographic Details
Main Authors: Benjamin J. Broadway, Paige K. Boneski, Jenny M. Bredenberg, Ana Kolicheski, Xu Hou, Alexandra I. Soto-Beasley, Owen A. Ross, Wolfdieter Springer, Fabienne C. Fiesel
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Cells
Subjects:
mitophagy
PINK1
PRKN
Parkin
Parkinson
PD genes
Online Access:https://www.mdpi.com/2073-4409/11/15/2426

Internet

https://www.mdpi.com/2073-4409/11/15/2426

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