8q24 clear cell renal cell carcinoma germline variant is associated with VHL mutation status and clinical aggressiveness

8q24 clear cell renal cell carcinoma germline variant is associated with VHL mutation status and clinical aggressiveness

Abstract Background The four most commonly-mutated genes in clear cell renal cell carcinoma (ccRCC) tumors are BAP1, PBRM1, SETD2 and VHL. And, there are currently 14 known RCC germline variants that have been reproducibly shown to be associated with RCC risk. However, the association of germline ge...

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Bibliographic Details
Main Authors: Jeanette E. Eckel-Passow, Huihuang Yan, Matthew L. Kosel, Daniel Serie, Paul A. Decker, Robert B. Jenkins, Brian Costello, Bradley Leibovich, Thai H. Ho, Alexander Parker
Format: Article
Language:English
Published: BMC 2020-10-01
Series:BMC Urology
Subjects:
Kidney
GWAS
Subtype
Hi-C
Online Access:http://link.springer.com/article/10.1186/s12894-020-00745-9

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http://link.springer.com/article/10.1186/s12894-020-00745-9

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