Divalent nanobodies to platelet CLEC-2 can serve as agonists or antagonists

Divalent nanobodies to platelet CLEC-2 can serve as agonists or antagonists

Fluorescence correlation spectroscopy on crosslinked nanobodies tested on C-type lectin-like receptor 2 (CLEC-2) show different outcomes for divalent and tetravalent nanobody ligands on CLEC-2 clustering, also dependent on CLEC-2 expression levels.

Bibliographic Details
Main Authors: Joanne C. Clark, Eleyna M. Martin, Luis A. Morán, Ying Di, Xueqing Wang, Malou Zuidscherwoude, Helena C. Brown, Deirdre M. Kavanagh, Johan Hummert, Johannes A. Eble, Bernhard Nieswandt, David Stegner, Alice Y. Pollitt, Dirk-Peter Herten, Michael G. Tomlinson, Angel García, Steve P. Watson
Format: Article
Language:English
Published: Nature Portfolio 2023-04-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-023-04766-6

Internet

https://doi.org/10.1038/s42003-023-04766-6

Similar Items