The Coincidence Between Increasing Age, Immunosuppression, and the Incidence of Patients With Glioblastoma

The Coincidence Between Increasing Age, Immunosuppression, and the Incidence of Patients With Glioblastoma

Background: Glioblastoma (GBM) is the most aggressive primary brain tumor in adults and is associated with a median overall survival (mOS) of 16–21 months. Our previous work found a negative association between advanced aging and the survival benefit after treatment with immunotherapy in an experime...

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Bibliographic Details
Main Authors: Erik Ladomersky, Denise M. Scholtens, Masha Kocherginsky, Elizabeth A. Hibler, Elizabeth T. Bartom, Sebastian Otto-Meyer, Lijie Zhai, Kristen L. Lauing, Jaehyuk Choi, Jeffrey A. Sosman, Jennifer D. Wu, Bin Zhang, Rimas V. Lukas, Derek A. Wainwright
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Pharmacology
Subjects:
aging
biomarker
IDO
immunosuppression
PD-L1
immunotherapy
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00200/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00200/full

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