A New Gnotobiotic Pig Model of P[6] Human Rotavirus Infection and Disease for Preclinical Evaluation of Rotavirus Vaccines

A New Gnotobiotic Pig Model of P[6] Human Rotavirus Infection and Disease for Preclinical Evaluation of Rotavirus Vaccines

Human rotavirus (HRV) is a leading cause of gastroenteritis in children under 5 years of age. Licensed vaccines containing G1P[8] and G1-4P[8] strains are less efficacious against newly emerging P[6] strains, indicating an urgent need for better cross protective vaccines. Here, we report our develop...

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Bibliographic Details
Main Authors: Charlotte Nyblade, Casey Hensley, Viviana Parreño, Peng Zhou, Maggie Frazier, Annie Frazier, Ashwin Ramesh, Shaohua Lei, Juan Ignacio Degiuseppe, Ming Tan, Lijuan Yuan
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Viruses
Subjects:
human rotavirus
P[6] genotype
gnotobiotic pig model
diarrhea
vaccine evaluation
Online Access:https://www.mdpi.com/1999-4915/14/12/2803

Internet

https://www.mdpi.com/1999-4915/14/12/2803

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