Effect of long-term antihypertensive treatment on cerebrovascular structure and function in hypertensive rats

Effect of long-term antihypertensive treatment on cerebrovascular structure and function in hypertensive rats

Abstract Midlife hypertension is an important risk factor for cognitive impairment and dementia, including Alzheimer’s disease. We investigated the effects of long-term treatment with two classes of antihypertensive drugs to determine whether diverging mechanisms of blood pressure lowering impact th...

Full description

Bibliographic Details
Main Authors:	Daphne M. P. Naessens, Judith de Vos, Edo Richard, Micha M. M. Wilhelmus, Cornelis A. M. Jongenelen, Edwin R. Scholl, Nicole N. van der Wel, Johannes A. Heijst, Charlotte E. Teunissen, Gustav J. Strijkers, Bram F. Coolen, Ed VanBavel, Erik N. T. P. Bakker
Format:	Article
Language:	English
Published:	Nature Portfolio 2023-03-01
Series:	Scientific Reports
Online Access:	https://doi.org/10.1038/s41598-023-30515-0

Similar Items

Altered brain fluid management in a rat model of arterial hypertension
by: Daphne M. P. Naessens, et al.
Published: (2020-06-01)

Blood–brain and blood–cerebrospinal fluid barrier permeability in spontaneously hypertensive rats
by: Daphne M. P. Naessens, et al.
Published: (2018-09-01)

Integrative modeling of small artery structure and function uncovers critical parameters for diameter regulation.
by: Ed VanBavel, et al.
Published: (2014-01-01)

THE ROLE OF ANTIHYPERTENSIVE MEDICATIONS IN THE MANAGEMENT OF CEREBROVASCULAR COMPLICATIONS IN ARTERIAL HYPERTENSION
by: N. U. Makhkamova, et al.
Published: (2009-12-01)

Regional contrast agent quantification in a mouse model of myocardial infarction using 3D cardiac T<sub>1 </sub>mapping
by: Nicolay Klaas, et al.
Published: (2011-10-01)

Incidence of neurodegenerative and cerebrovascular diseases associated with antihypertensive drug classes
by: Harrison, PJ, et al.
Published: (2021)

Highly accelerated 4D flow cardiovascular magnetic resonance using a pseudo-spiral Cartesian acquisition and compressed sensing reconstruction for carotid flow and wall shear stress
by: Eva S. Peper, et al.
Published: (2020-01-01)

Increase in endoplasmic reticulum-associated tissue transglutaminase and enzymatic activation in a cellular model of Parkinson's disease
by: Robin Verhaar, et al.
Published: (2012-03-01)

Antihypertensive therapy in patients with cerebrovascular pathology: actual aspects and rational approaches
by: Z. A. Suslina, et al.
Published: (2005-06-01)

Vectorial wall shear stress calculations in vessel structures using 4D PC-MRI
by: Potters Wouter V, et al.
Published: (2012-02-01)

Iron Oxide Nanoparticle Uptake in Mouse Brachiocephalic Artery Atherosclerotic Plaque Quantified by T<sub>2</sub>-Mapping MRI
by: Rik P. M. Moonen, et al.
Published: (2021-02-01)

From Molecules to Imaging: Assessment of Placental Hypoxia Biomarkers in Placental Insufficiency Syndromes
by: Fatimah M. Al Darwish, et al.
Published: (2023-08-01)

Heterogeneity in arterial remodeling among sublines of spontaneously hypertensive rats.
by: Erik N T P Bakker, et al.
Published: (2014-01-01)

The Transglutaminase-2 Interactome in the APP23 Mouse Model of Alzheimer’s Disease
by: Micha M. M. Wilhelmus, et al.
Published: (2022-01-01)

Gene Expression and MicroRNA Expression Analysis in Small Arteries of Spontaneously Hypertensive Rats. Evidence for ER Stress.
by: Teresa Palao, et al.
Published: (2015-01-01)

Wall shear stress vectors derived from 3D PC-MRI at increasing resolutions in an intracranial aneurysm phantom
by: van Ooij Pim, et al.
Published: (2012-02-01)

Impairment of Cerebrovascular Hemodynamics in Patients With Severe and Milder Forms of Sickle Cell Disease
by: Liza Afzali-Hashemi, et al.
Published: (2021-04-01)

Comparison of four MR carotid surface coils at 3T.
by: Qinwei Zhang, et al.
Published: (2019-01-01)

Locally advanced rectal cancer: 3D diffusion-prepared stimulated-echo turbo spin-echo versus 2D diffusion-weighted echo-planar imaging
by: Qinwei Zhang, et al.
Published: (2020-02-01)

Thinking about the action potential: the nerve signal as a window to the physical principles guiding neuronal excitability
by: Benjamin Drukarch, et al.
Published: (2023-08-01)

Differential Expression of Tissue Transglutaminase Splice Variants in Peripheral Blood Mononuclear Cells of Primary Progressive Multiple Sclerosis Patients
by: Claudia Sestito, et al.
Published: (2018-11-01)

Correction: Characterization of Transglutaminase 2 activity inhibitors in monocytes in vitro and their effect in a mouse model for multiple sclerosis.
by: Navina L Chrobok, et al.
Published: (2018-01-01)

An isolated beating pig heart platform for a comprehensive evaluation of intracardiac blood flow with 4D flow MRI: a feasibility study
by: Eva S. Peper, et al.
Published: (2019-10-01)

Coronary Flow Assessment Using Accelerated 4D Flow MRI With Respiratory Motion Correction
by: Carmen P. S. Blanken, et al.
Published: (2021-08-01)

Quantification and visualization of flow in small vessels of the Circle of Willis: time-resolved three-dimensional phase contrast MRI at 7T compared with 3T
by: van Ooij Pim, et al.
Published: (2012-02-01)

Doença cerebrovascular.
by: J M Ferro
Published: (1997-09-01)

A 3-slice cardiac quantitative native and post-contrast T1 and T2 MRI protocol requiring only four BHs using a 72-channel receive array coil
by: Hugo Klarenberg, et al.
Published: (2023-11-01)

A Comparative Study of Polarization Management Around Energy Transition-Related Land-Use Conflicts in The Netherlands
by: Christian Scholl, et al.
Published: (2023-06-01)

Embryonic cardiomyocyte, but not autologous stem cell transplantation, restricts infarct expansion, enhances ventricular function, and improves long-term survival.
by: Leonie E Paulis, et al.
Published: (2013-01-01)

Current approach to antihypertensive therapy
by: M. V. Kuznetsova
Published: (2015-12-01)

Combined antihypertensive medications
by: L. L. Kirichenko, et al.
Published: (2007-12-01)

Dynamics of the aortic annulus in 4D CT angiography for transcatheter aortic valve implantation patients.
by: Mustafa A Elattar, et al.
Published: (2017-01-01)

A 72-channel receive array coil allows whole-heart cine MRI in two breath holds
by: Hugo Klarenberg, et al.
Published: (2022-11-01)

20-HETE Enzymes and Receptors in the Neurovascular Unit: Implications in Cerebrovascular Disease
by: Ezekiel Gonzalez-Fernandez, et al.
Published: (2020-09-01)

Comorbidities in cerebrovascular diseases
by: M. M. Tanashyan, et al.
Published: (2017-02-01)

Enfermedad cerebrovascular en Colombia Cerebrovascular disease in Colombia
by: Federico A Silva, et al.
Published: (2006-10-01)

Modern combination antihypertensive pharmacotherapy
by: O A Mubarakshina, et al.
Published: (2018-12-01)

Antihypertensive agents /
by: Engelhardt, Edward L.
Published: (1976)

Antihypertensive effects of angiotensin-(1-7)
by: M.C. Chappell, et al.
Published: (1998-09-01)

EFFICACY AND TOLERABILITY OF NEBIVOLOL COMPARED WITH OTHER ANTIHYPERTENSIVE DRUGS: A META-ANALYSIS
by: L. M. Van Bortel, et al.
Published: (2011-02-01)