Upregulation of MELK promotes chemoresistance and induces macrophage M2 polarization via CSF-1/JAK2/STAT3 pathway in gastric cancer

Upregulation of MELK promotes chemoresistance and induces macrophage M2 polarization via CSF-1/JAK2/STAT3 pathway in gastric cancer

Abstract Background Gastric cancer (GC) stands out as one of the most prevalent malignancies affecting the digestive system, characterized by a substantial incidence rate and mortality. Maternal embryonic leucine zipper kinase (MELK) has been implicated in the advancement of various cancer types and...

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Bibliographic Details
Main Authors: Pengfei Su, Tian Yu, Yingjing Zhang, Hongyun Huang, Moxi Chen, Can Cao, Weiming Kang, Yuqin Liu, Jianchun Yu
Format: Article
Language:English
Published: BMC 2024-08-01
Series:Cancer Cell International
Subjects:
Gastric cancer
MELK
Chemoresistance
Tumor-associated macrophages
Polarization
Prognosis
Online Access:https://doi.org/10.1186/s12935-024-03453-8

Internet

https://doi.org/10.1186/s12935-024-03453-8

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