Didymin alleviates metabolic dysfunction-associated fatty liver disease (MAFLD) via the stimulation of Sirt1-mediated lipophagy and mitochondrial biogenesis

Didymin alleviates metabolic dysfunction-associated fatty liver disease (MAFLD) via the stimulation of Sirt1-mediated lipophagy and mitochondrial biogenesis

Abstract Background Metabolic dysfunction-associated fatty liver disease (MAFLD) is one of the most prevalent metabolic syndromes worldwide. However, no approved pharmacological treatments are available for MAFLD. Chenpi, one kind of dried peel of citrus fruits, has traditionally been utilized as a...

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Bibliographic Details
Main Authors: Jing-wen Yang, Ying Zou, Jun Chen, Chen Cui, Jia Song, Meng-meng Yang, Jing Gao, Hui-qing Hu, Long-qing Xia, Li-ming Wang, Xiao-yu Lv, Li Chen, Xin-guo Hou
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Journal of Translational Medicine
Subjects:
Didymin
Sirt1
MAFLD
Mitochondrial function
Lipophagy
Apoptosis
Online Access:https://doi.org/10.1186/s12967-023-04790-4

Internet

https://doi.org/10.1186/s12967-023-04790-4

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