Case Report: Rubella Virus-Induced Cutaneous Granulomas in Two Pediatric Patients With DNA Double Strand Breakage Repair Disorders – Outcome After Hematopoietic Stem Cell Transplantation

Case Report: Rubella Virus-Induced Cutaneous Granulomas in Two Pediatric Patients With DNA Double Strand Breakage Repair Disorders – Outcome After Hematopoietic Stem Cell Transplantation

We report two patients with DNA repair disorders (Artemis deficiency, Ataxia telangiectasia) with destructive skin granulomas, presumably triggered by live-attenuated rubella vaccinations. Both patients showed reduced naïve T cells. Rapid resolution of skin lesions was observed following hematopoiet...

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Bibliographic Details
Main Authors: Ulrich Baumann, Johannes H. Schulte, Jonathan P. Groß, Rita Beier, Marius Ludwig, Volker Wahn, Jörg Hofmann, Britta Maecker-Kolhoff, Martin Sauer, Petra Kaiser-Labusch, Negin Karimian, Ulrike Blume-Peytavi, Franziska Ghoreschi, Hagen Ott, Ludmila Perelygina, Christian Klemann, Oliver Blankenstein, Horst von Bernuth, Renate Krüger
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Immunology
Subjects:
inborn errors of immunity
primary immunodeficiency
Ataxia telangiectasia
Artemis deficiency
rubella virus vaccine strain
granuloma formation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.886540/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.886540/full

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