T-bet is a key modulator of IL-23-driven pathogenic CD4+ T cell responses in the intestine

T-bet is a key modulator of IL-23-driven pathogenic CD4+ T cell responses in the intestine

How transcription factor T-bet and Th17 cells contribute to colitis remains incompletely understood. Here the authors identify T-bet as a negative regulator of IL-23R pathway activation and show that T-bet deficient T cells drive colitogenic Th17 responses dependent on the cytokines IL-17A and IL-22...

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Bibliographic Details
Main Authors: Thomas Krausgruber, Chris Schiering, Krista Adelmann, Oliver J. Harrison, Agnieszka Chomka, Claire Pearson, Philip P. Ahern, Matthew Shale, Mohamed Oukka, Fiona Powrie
Format: Article
Language:English
Published: Nature Portfolio 2016-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms11627

Internet

https://doi.org/10.1038/ncomms11627

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