Loss of Rbl2 (Retinoblastoma‐Like 2) Exacerbates Myocardial Ischemia/Reperfusion Injury

Loss of Rbl2 (Retinoblastoma‐Like 2) Exacerbates Myocardial Ischemia/Reperfusion Injury

Background The postmitotic state of adult cardiomyocytes, maintained by the cell cycle repressor Rbl2 (retinoblastoma‐like 2), is associated with considerable resistance to apoptosis. However, whether Rbl2 regulates cardiomyocyte apoptosis remains unknown. Methods and Results Here, we show that abla...

Full description

Bibliographic Details
Main Authors: Jingrui Chen, Peng Xia, Yuening Liu, Clark Kogan, Zhaokang Cheng
Format: Article
Language:English
Published: Wiley 2022-10-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
apoptosis
cardiac myocytes
cell cycle
cell death
cyclin‐dependent kinase
myocardial infarction
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.121.024764

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.121.024764

Similar Items