Ameliorating cancer cachexia by inhibiting cancer cell release of Hsp70 and Hsp90 with omeprazole

Ameliorating cancer cachexia by inhibiting cancer cell release of Hsp70 and Hsp90 with omeprazole

Abstract Background Cancer cachexia, characterized by muscle and fat tissue wasting, is a major determinant of cancer‐related mortality without established treatment. Recent animal data revealed that cancer cells induce muscle wasting by releasing Hsp70 and Hsp90 as surface proteins on extracellular...

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Bibliographic Details
Main Authors: Zhelong Liu, Jian Xiong, Song Gao, Michael X. Zhu, Kai Sun, Min Li, Guohua Zhang, Yi‐Ping Li
Format: Article
Language:English
Published: Wiley 2022-02-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
Lewis lung carcinoma
Muscle wasting
Fat tissue wasting
Hsp70
Hsp90
Rab27b
Online Access:https://doi.org/10.1002/jcsm.12851

Internet

https://doi.org/10.1002/jcsm.12851

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