Predominantly Antibody-Deficient Patients With Non-infectious Complications Have Reduced Naive B, Treg, Th17, and Tfh17 Cells

Predominantly Antibody-Deficient Patients With Non-infectious Complications Have Reduced Naive B, Treg, Th17, and Tfh17 Cells

Background: Patients with predominantly antibody deficiency (PAD) suffer from severe and recurrent infections that require lifelong immunoglobulin replacement and prophylactic antibiotic treatment. Disease incidence is estimated to be 1:25,000 worldwide, and up to 68% of patients develop non-infecti...

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Bibliographic Details
Main Authors: Emily S. J. Edwards, Julian J. Bosco, Pei M. Aui, Robert G. Stirling, Paul U. Cameron, Josh Chatelier, Fiona Hore-Lacy, Robyn E. O'Hehir, Menno C. van Zelm
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Immunology
Subjects:
predominantly antibody deficiency
common variable immunodeficiency
autoimmunity
X-linked agammaglobulinemia
follicular helper T cells
CD21lo B cells
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02593/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.02593/full

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