CD44 Promotes Migration and Invasion of Docetaxel-Resistant Prostate Cancer Cells Likely via Induction of Hippo-Yap Signaling

CD44 Promotes Migration and Invasion of Docetaxel-Resistant Prostate Cancer Cells Likely via Induction of Hippo-Yap Signaling

Patients receiving docetaxel developed a drug resistance within a few months. We generated docetaxel-resistant PC/DX25 and DU/DX50 CRPC cells from PC-3 and DU-145 PCa cells, respectively. We investigated the mechanism behind why PC/DX25 and DU/DX50 cells exhibited higher migration and invasion abili...

Full description

Bibliographic Details
Main Authors: Chih-Jen Lai, Ching-Yu Lin, Wen-Ying Liao, Tzyh-Chyuan Hour, Horng-Dar Wang, Chih-Pin Chuu
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Cells
Subjects:
prostate cancer
CD44
YAP
docetaxel-resistant
migration
invasion
PC-3
DU-145
Online Access:https://www.mdpi.com/2073-4409/8/4/295

Internet

https://www.mdpi.com/2073-4409/8/4/295

Similar Items